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Synthetic Nicotine

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Recently, you may have noticed that many of the new products on our site are made with “synthetic nicotine” or alternatively, “tobacco-free nicotine.” While these terms are relatively new and often used interchangeably, there are important distinctions to be made between them. Keep reading to learn more about what synthetic nicotine is, and why it has become such a popular choice for adult vape enthusiasts and vape manufacturers.

What Is Synthetic Nicotine?

In the simplest terms, Synthetic Nicotine is man-made nicotine that has been created in a lab, rather than derived from tobacco.

Is Synthetic Nicotine Different from Regular Nicotine?

Yes—there are some differences between synthetic nicotine and regular nicotine, namely in how they are made and how they are regulated by the FDA. In addition, some adult users have reported that the experience of vaping synthetic nicotine differs from that of regular nicotine.

How Is Synthetic Nicotine Made?

While all synthetic nicotine products are man-made, several methods have been developed for the synthesis of nicotine by various chemists and manufacturers. The chemistry behind synthetic nicotine is complex and the precise methods used to create synthetic nicotine vary, depending on the synthetic nicotine type used and the specific product in question.

For example, some synthetic nicotine products are made with “TFN” synthetic nicotine, which is a trademarked brand of tobacco-free nicotine that is manufactured by the company, Next Generation Labs (NGL). The pathway for creating this specific version of synthetic nicotine, TFN, is outlined in Next Generation Lab's patent and differs from those used by manufacturers who aren't licensed to describe their synthetic nicotine products under this acronym.

Is Synthetic Nicotine Safe?

Electric Tobacconist is an online retailer and is not qualified to provide medical advice or comment on the safety or efficacy of synthetic nicotine. We encourage our responsible, adult customers to do their own research and evaluate the risks of using synthetic nicotine and nicotine in general, accordingly.

Types of Synthetic Nicotine: Tobacco-Free Nicotine Vs. “TFN” Vs. Tobacco Leaf-Free Nicotine

There are several types of nicotine that fall under the synthetic nicotine 'family tree'. The chart below illustrates how some of the common types of nicotine are distinguished between these two categories:

Nicotine Family Tree: Types of Naturally-Derived & Synthetic Nicotine

Synthetic Nicotine Chart

Synthetic Nicotine Chart

Types of Non-Synthetic, aka “Naturally-Derived” Nicotine 

What we might think of as “traditional” or “regular” nicotine would be considered non-synthetic nicotine, as it is naturally-derived, rather than synthetically-created. Tobacco-leaf-free nicotine simply means that the nicotine was created without the use of the tobacco leaf; however, tobacco-leaf-free nicotine products may utilize other parts of the tobacco plant in their nicotine products.


Non-Synthetic Nicotine

 
  • Tobacco-Leaf Free Nicotine
  • Tobacco-Derived Nicotine

Synthetic Nicotine

 
  • Tobacco-Free Nicotine
  • Synthetic Nicotine
  • TFN™

Non-Synthetic Nicotine

 
  • Tobacco-Leaf Free Nicotine
  • Tobacco-Derived Nicotine
 

Synthetic Nicotine

 
  • Tobacco-Free Nicotine
  • Synthetic Nicotine
  • TFN™

Types of Synthetic Nicotine

There are three main types of nicotine that fall under what we consider the 'synthetic nicotine umbrella': tobacco-free nicotine, TFN™, and synthetic nicotine. The phrases “tobacco-free nicotine” and “synthetic nicotine” are often used by manufacturers interchangeably to describe any type of nicotine that was man-made in a lab, rather than naturally derived. “TFN™” is a trademarked brand of tobacco-free nicotine that is manufactured by the company, Next Generation Labs (NGL), however. The pathway for creating this specific version of synthetic nicotine, TFN, is outlined in Next Generation Lab's patent and differs from those used by manufacturers who aren't licensed to describe their synthetic nicotine products under this acronym. You can read the full patent for TFN™ here. Products that are made with this brand of nicotine are identified with the trademark registered by Next Generation Labs.

Why Are So Many Vaping Products Being Made with Synthetic Nicotine?

While the use of synthetic nicotine had been considered as early as the 1960s, many believe that the sudden swell in synthetic nicotine products can be largely attributed to the recent PMTA rulings by the FDA. Many brands that did not receive a PMTA acceptance letter have opted to re-release their product ranges with synthetic nicotine, due to the fact that synthetic nicotine products were not required to apply for a PMTA in order to remain on the market. You can read more about this on the FDA's FAQ page.

FDA Regulations On Vaping: What Is “PMTA” and What Does It Have to Do With Synthetic Nicotine?

PMTA is an acronym for “Premarket Tobacco Product Application.” If you'd like to view an in-depth explanation of PMTA, please visit our page: What is PMTA, and what does it mean for the vape industry? Many brands that did not receive a PMTA acceptance letter have recently opted to re-release their product ranges with synthetic nicotine, due to the fact that synthetic nicotine products were not required to apply for a PMTA in order to remain on the market.

What Kind(s) of Synthetic Nicotine Products Does Electric Tobacconist Offer?

Electric Tobacconist is the proud stockist of a wide selection of synthetic nicotine vaping products. We currently offer a range of synthetic nicotine disposables, e-liquids, and nicotine alternatives, all of which are available for purchase at our online vape store

 Sources & Further Reading

Products, Center for Tobacco. “ FDA Center for Tobacco Products Commonly Asked Questions.” U.S. Food and Drug Administration, FDA, https://www.fda.gov/tobacco-products/about-center-tobacco-products-ctp/commonly-asked-questions-about-center-tobacco-products#14. 

Jordt, Sven-Eric. “ Synthetic Nicotine Has Arrived.” Tobacco Control, BMJ Publishing Group Ltd, 7 Sept. 2021, https://tobaccocontrol.bmj.com/content/early/2021/09/07/tobaccocontrol-2021-056626. 

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